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Issue 5, 2011
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Synthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors

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Abstract

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone bradykinin (a nonapeptide) to inactivate this hormone. Therefore, inhibition of ACE is generally used as one of the methods for the treatment of hypertension. ‘Oxidative stress’ is another disease state caused by an imbalance in the production of oxidants and antioxidants. A number of studies suggest that hypertension and oxidative stress are interdependent. Therefore, ACE inhibitors having antioxidant property are considered beneficial for the treatment of hypertension. As selenium compounds are known to exhibit better antioxidant behavior than their sulfur analogues, we have synthesized a number of selenium analogues of captopril, an ACE inhibitor used as an antihypertensive drug. The selenium analogues of captopril not only inhibit ACE activity but also effectively scavenge peroxynitrite, a strong oxidant found in vivo.

Graphical abstract: Synthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors

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Publication details

The article was received on 04 Oct 2010, accepted on 04 Nov 2010 and first published on 09 Nov 2010


Article type: Paper
DOI: 10.1039/C0OB00823K
Citation: Org. Biomol. Chem., 2011,9, 1356-1365
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    Synthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors

    B. J. Bhuyan and G. Mugesh, Org. Biomol. Chem., 2011, 9, 1356
    DOI: 10.1039/C0OB00823K

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