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Issue 9, 2011
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Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer

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Abstract

Microfluidic technology has been used to perform [11C]carbonylation reactions using solutions containing [11C]CO in the form of the complex, copper(I)tris(3,5-dimethylpyrazolyl)borate-[11C]carbonyl (Cu(Tp*)[11C]CO). The synthesis of the model compound [11C]N-benzylbenzamide and the known tracer molecule [11C]trans-N-[5-(2-flurophenyl)-2-pyrimidinyl]-3-oxospiro[5-azaisobenzofurane-1(3H),1′-cyclohexane]-4′-carboxamide ([11C]MK-0233), a ligand for the neuropeptide Y Y5 receptor, have been performed using this technique. Following semi-preparative HPLC purification and reformulation, 1262 ± 113 MBq of [11C]MK-0233 was produced at the end of the synthesis with a specific activity of 100 ± 30 GBq μmol−1 and a >99% radiochemical purity. This corresponds to a decay corrected radiochemical yield of 7.2 ± 0.7%. Using a 3 mL vial as the reaction vessel, and following semi-preparative HPLC purification and reformulation, 1255 ± 392 MBq of [11C]MK-0233 was produced at the end of the synthesis with a specific activity of 100 ± 15 GBq μmol−1 and a >99% radiochemical purity. This corresponds to a decay corrected radiochemical yield of 7.1 ± 2.2%.

Graphical abstract: Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer

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Publication details

The article was received on 26 Aug 2010, accepted on 06 Jan 2011 and first published on 25 Mar 2011


Article type: Paper
DOI: 10.1039/C0OB00631A
Citation: Org. Biomol. Chem., 2011,9, 3313-3319
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    Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer

    S. Kealey, C. Plisson, T. L. Collier, N. J. Long, S. M. Husbands, L. Martarello and A. D. Gee, Org. Biomol. Chem., 2011, 9, 3313
    DOI: 10.1039/C0OB00631A

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