Issue 3, 2011

Stereoselective synthesis of the C15–C26 fragment of the antitumor agent (−)-dictyostatin

Abstract

The synthesis of the C15–C26 fragment of (−)-dictyostatin is reported in 10 steps and 28% overall yield. The key steps are the two stereoselective sulfoxide-directed processes: a Reformatsky-type reaction and a β-keto sulfoxide reduction.

Graphical abstract: Stereoselective synthesis of the C15–C26 fragment of the antitumor agent (−)-dictyostatin

Supplementary files

Article information

Article type
Paper
Submitted
26 Jul 2010
Accepted
30 Sep 2010
First published
17 Nov 2010

Org. Biomol. Chem., 2011,9, 758-764

Stereoselective synthesis of the C15–C26 fragment of the antitumor agent (−)-dictyostatin

L. Ferreiro-Mederos, S. Vila-Gisbert, A. Urbano, M. C. Carreño and F. Colobert, Org. Biomol. Chem., 2011, 9, 758 DOI: 10.1039/C0OB00491J

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