Jump to main content
Jump to site search

Issue 11, 2011
Previous Article Next Article

Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis

Author affiliations

Abstract

Multi-hydroxylated endohedral metallofullerenol [Gd@C82(OH)22]n nanoparticles possess the general physico-chemical characteristics of most nanoparticles. They also exhibit uniquely low toxicity and antineoplastic efficacy. In the current study, the molecular mechanisms and epigenetic characteristics of the antineoplastic action of these nanoparticles are explored. Human breast cancer MCF-7 and human umbilical vein endothelial ECV304 cell lines were used. Cell viability assay, cell hierarchical cluster analysis by cDNA microarray, semi-quantitative reverse transcription-polymerase chain reaction and Western blot analysis were conducted to investigate the changes in molecular and cellular signaling pathways caused by [Gd@C82(OH)22]n. The results demonstrated the high antitumor activity and low cytotoxicity of [Gd@C82(OH)22]n nanoparticles both in vivo and in vitro. Their possible anti-tumor mechanisms were also discussed. The present study may provide new insight into the mechanism of action of these nanoparticles.

Graphical abstract: Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis

Back to tab navigation

Publication details

The article was received on 21 Jul 2011, accepted on 03 Sep 2011 and first published on 04 Oct 2011


Article type: Paper
DOI: 10.1039/C1NR10898K
Citation: Nanoscale, 2011,3, 4713-4719
  •   Request permissions

    Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: in vivo treatment and in vitro analysis

    J. Meng, J. Xing, Y. Wang, J. Lu, Y. Zhao, X. Gao, P. C. Wang, L. Jia and X. Liang, Nanoscale, 2011, 3, 4713
    DOI: 10.1039/C1NR10898K

Search articles by author

Spotlight

Advertisements