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Issue 3, 2011
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The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures

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Abstract

RADA16 self-assembling peptide nanofiber scaffolds (SAPNSs) have been shown to have positive effects on neural regeneration following injury to the central nervous system in vivo, but mechanisms are unclear. Here we show that RADA16 SAPNSs form scaffolds of increasing fiber density with increasing peptide concentration which in turn has a concentration-dependent effect on neurons and astrocytes in mixed retinal cultures. Importantly, we report that the final nanoscale fiber architecture is an important factor to consider in designing scaffolds to promote regeneration in the central nervous system.

Graphical abstract: The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures

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Publication details

The article was received on 10 Sep 2010, accepted on 15 Oct 2010 and first published on 03 Dec 2010


Article type: Communication
DOI: 10.1039/C0NR00666A
Citation: Nanoscale, 2011,3, 907-910
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    The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures

    D. Ho, M. Fitzgerald, C. A. Bartlett, B. Zdyrko, I. A. Luzinov, S. A. Dunlop and K. Swaminathan Iyer, Nanoscale, 2011, 3, 907
    DOI: 10.1039/C0NR00666A

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