Issue 3, 2011
From the journal:

Nanoscale

The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures†

Dominic Ho,ab   Melinda Fitzgerald,b   Carole A. Bartlett,b   Bogdan Zdyrko,c   Igor A. Luzinov,c   Sarah A. Dunlop*b  and  K. Swaminathan Iyer*a  

* Corresponding authors

a School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Crawley, Australia
E-mail: swaminatha.iyer@uwa.edu.au
Tel: +61 8 6488 4470

b Experimental and Regenerative Neurosciences, School of Animal Biology, The University of Western Australia, Perth, Australia
E-mail: sarah.dunlop@uwa.edu.au
Fax: +61 8 6488 7527
Tel: +61 8 6488 1403

c School of Materials Science and Engineering, Clemson University, 161 Sirrine Hall, Clemson, South Carolina, USA

Abstract

RADA16 self-assembling peptide nanofiber scaffolds (SAPNSs) have been shown to have positive effects on neural regeneration following injury to the central nervous system in vivo, but mechanisms are unclear. Here we show that RADA16 SAPNSs form scaffolds of increasing fiber density with increasing peptide concentration which in turn has a concentration-dependent effect on neurons and astrocytes in mixed retinal cultures. Importantly, we report that the final nanoscale fiber architecture is an important factor to consider in designing scaffolds to promote regeneration in the central nervous system.

Graphical abstract: The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures

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Article information

DOI
https://doi.org/10.1039/C0NR00666A
Article type
Communication
Submitted
10 Sep 2010
Accepted
15 Oct 2010
First published
03 Dec 2010

Nanoscale, 2011,3, 907-910

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The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures

D. Ho, M. Fitzgerald, C. A. Bartlett, B. Zdyrko, I. A. Luzinov, S. A. Dunlop and K. Swaminathan Iyer, Nanoscale, 2011, 3, 907 DOI: 10.1039/C0NR00666A

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