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Issue 2, 2011
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Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles

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Abstract

We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed.

Graphical abstract: Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles

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Publication details

The article was received on 23 Jun 2010, accepted on 03 Sep 2010 and first published on 29 Sep 2010


Article type: Communication
DOI: 10.1039/C0NR00436G
Citation: Nanoscale, 2011,3, 387-390
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    Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles

    E. Occhipinti, P. Verderio, A. Natalello, E. Galbiati, M. Colombo, S. Mazzucchelli, A. Salvadè, P. Tortora, S. M. Doglia and D. Prosperi, Nanoscale, 2011, 3, 387
    DOI: 10.1039/C0NR00436G

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