Issue 8, 2011

Natural products containing a diazo group

Abstract

Covering: up to the end of March 2011

Although diazo compounds are probably best known for their involvement as versatile intermediates in modern synthetic organic chemistry, a small number of such compounds also occur naturally. Many of the early examples, such as azaserine, originally isolated in the 1950s, have antitumour properties and consist of modified α-amino acids. More recently, other more complex diazo compounds have been isolated from natural sources, and these include diazobenzoquinones, diazonaphthoquinones, such as the SF2415 and A80915 antibiotics, and the diazofluorene-based kinamycins and lomaiviticins. This report will cover the isolation, biosynthesis, biological activity and synthesis of natural products containing a diazo group.

Graphical abstract: Natural products containing a diazo group

Article information

Article type
Review Article
Submitted
07 Apr 2011
First published
18 May 2011

Nat. Prod. Rep., 2011,28, 1426-1444

Natural products containing a diazo group

C. C. Nawrat and C. J. Moody, Nat. Prod. Rep., 2011, 28, 1426 DOI: 10.1039/C1NP00031D

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