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Issue 11, 2011
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One-pot microwave-assisted synthesis and antimalarial activity of ferrocenyl benzodiazepines

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Abstract

An efficient synthesis of 1,4-benzodiazepin-2-ones is described by condensation between 2-aminobenzophenone and Boc-protected amino acids via microwave-assisted irradiation. This produces higher yields in shorter reaction times than with traditional methods. The antiplasmodial activity of the corresponding ferrocenyl benzodiazepines was evaluated in vitro against Plasmodium falciparum F32 (chloroquine-sensitive) and FCB1 and K1 (chloroquine-resistant) strains and gabonese clinical isolates.

Graphical abstract: One-pot microwave-assisted synthesis and antimalarial activity of ferrocenyl benzodiazepines

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Publication details

The article was received on 22 Jun 2011, accepted on 30 Aug 2011 and first published on 28 Sep 2011


Article type: Letter
DOI: 10.1039/C1NJ20551J
Citation: New J. Chem., 2011,35, 2412-2415
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    One-pot microwave-assisted synthesis and antimalarial activity of ferrocenyl benzodiazepines

    G. Mwande-Maguene, J. Jakhlal, J. Lekana-Douki, E. Mouray, T. Bousquet, S. Pellegrini, P. Grellier, F. S. T. Ndouo, J. Lebibi and L. Pelinski, New J. Chem., 2011, 35, 2412
    DOI: 10.1039/C1NJ20551J

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