Issue 7, 2011

α,β-D-CNA featuring canonical and noncanonical α/β torsional angles behaviours within oligonucleotides

Abstract

α,β-D-CNA building blocks featuring either canonical gauche(−) or noncanonical gauche(+) values of the nucleic acids sugar phosphate backbone torsional angle α have been introduced into oligonucleotides, and provide new insight on conformational restriction impact on duplex formation ability by means of UV experiments and molecular dynamics simulations.

Graphical abstract: α,β-D-CNA featuring canonical and noncanonical α/β torsional angles behaviours within oligonucleotides

Supplementary files

Article information

Article type
Paper
Submitted
31 Jan 2011
Accepted
20 Apr 2011
First published
17 May 2011

New J. Chem., 2011,35, 1528-1533

α,β-D-CNA featuring canonical and noncanonical α/β torsional angles behaviours within oligonucleotides

A. Boissonnet, C. Dupouy, P. Millard, M. Durrieu, N. Tarrat and J. Escudier, New J. Chem., 2011, 35, 1528 DOI: 10.1039/C1NJ20086K

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