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Issue 12, 2011
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Combination of PAGE and LA-ICP-MS as an analytical workflow in metallomics: state of the art, new quantification strategies, advantages and limitations

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Abstract

Metallomics (more specifically, metalloproteomics) is an emerging field that encompasses the role, uptake, transport and storage of trace metals, which are essential to preserve the functions of proteins within a biological system. The current strategies for metal-binding and metalloprotein analysis based on the combination of polyacrylamide gel electrophoresis (PAGE) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) are discussed in this review. The advantages, limitations and the most recently developed and applied quantification approaches for this methodology are also described.

Graphical abstract: Combination of PAGE and LA-ICP-MS as an analytical workflow in metallomics: state of the art, new quantification strategies, advantages and limitations

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Publication details

The article was received on 26 Jul 2011, accepted on 10 Oct 2011 and first published on 24 Oct 2011


Article type: Critical Review
DOI: 10.1039/C1MT00116G
Citation: Metallomics, 2011,3, 1271-1279
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    Combination of PAGE and LA-ICP-MS as an analytical workflow in metallomics: state of the art, new quantification strategies, advantages and limitations

    A. Sussulini and J. S. Becker, Metallomics, 2011, 3, 1271
    DOI: 10.1039/C1MT00116G

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