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Issue 6, 2011
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Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

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Abstract

(E)- and (Z)-3-Ferrocenylmethylidene-1,3-dihydro-2H-indol-2-ones 1 have been structurally modified in order to explore SAR against a range of kinases. Of note is the submicromolar to low micromolar inhibition of DYRK3 and 4 by a number of complexes. Screening using Xenopus embryos showed some of the compounds to have potent antiangiogenisis activity.

Graphical abstract: Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

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Publication details

The article was received on 01 Feb 2011, accepted on 08 Feb 2011 and first published on 01 Mar 2011


Article type: Paper
DOI: 10.1039/C1MT00017A
Citation: Metallomics, 2011,3, 600-608
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    Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

    J. Spencer, J. Amin, S. K. Callear, G. J. Tizzard, S. J. Coles, P. Coxhead and M. Guille, Metallomics, 2011, 3, 600
    DOI: 10.1039/C1MT00017A

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