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Issue 3, 2011
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Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins

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Abstract

This review examines recent studies on the thermodynamics of copper association with amyloid-β, α-synuclein and prion protein, with an eye towards using this information to understand the etiology of associated neurodegenerative diseases. A variety of binding affinities and binding sites, which are essential to understand the function and consequence of copper-protein interaction, have been reported for copper to these three neurobiologic systems. This current review reconciles the disparate models presented in the literature.

Graphical abstract: Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins

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Publication details

The article was received on 24 Sep 2010, accepted on 08 Nov 2010 and first published on 29 Nov 2010


Article type: Minireview
DOI: 10.1039/C0MT00052C
Citation: Metallomics, 2011,3, 262-266
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    Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins

    L. Hong and J. D. Simon, Metallomics, 2011, 3, 262
    DOI: 10.1039/C0MT00052C

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