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Issue 7, 2011
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Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

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Abstract

This first in vivo antitumour activity for an organometallic osmium arene complex, [Os(η6-p-cym)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF6, is reported. The complex delays the growth of HCT116 human colon cancer xenografts in mice, with negligible toxicity. Its activity appears to involve redox mechanisms and its potency towards A2780 ovarian and A549 lung cancer cells is increased significantly in combination with L-buthionine-sulfoximine.

Graphical abstract: Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

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Publication details

The article was received on 15 Mar 2011, accepted on 10 Apr 2011 and first published on 19 May 2011


Article type: Concise Article
DOI: 10.1039/C1MD00075F
Citation: Med. Chem. Commun., 2011,2, 666-668
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    Anti-colorectal cancer activity of an organometallic osmium arene azopyridine complex

    S. D. Shnyder, Y. Fu, A. Habtemariam, S. H. van Rijt, P. A. Cooper, P. M. Loadman and P. J. Sadler, Med. Chem. Commun., 2011, 2, 666
    DOI: 10.1039/C1MD00075F

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