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Issue 5, 2011
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Ester prodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies

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Abstract

Novel ester prodrugs of ciprofloxacin were synthesized, and tested for their antimalarial and antitoxoplasma activity. These new compounds proved to be extremely efficient against these parasites. Molecular modeling and computational calculations were used to understand the mechanisms of action of these drugs.

Graphical abstract: Ester prodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies

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Publication details

The article was received on 20 Jan 2011, accepted on 03 Mar 2011 and first published on 17 Mar 2011


Article type: Concise Article
DOI: 10.1039/C1MD00022E
Citation: Med. Chem. Commun., 2011,2, 430-435
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    Ester prodrugs of ciprofloxacin as DNA-gyrase inhibitors: synthesis, antiparasitic evaluation and docking studies

    F. Dubar, R. Wintjens, É. S. Martins-Duarte, R. C. Vommaro, W. de Souza, D. Dive, C. Pierrot, B. Pradines, A. Wohlkonig, J. Khalife and C. Biot, Med. Chem. Commun., 2011, 2, 430
    DOI: 10.1039/C1MD00022E

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