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Issue 5, 2011
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Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

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Abstract

The C-fucosyl peptide dendrimer D-FD2 (CFuc-lys-pro-leu)4(Lys-phe-lys-leu)2Lys-his-leu-NH2 was prepared as the D-amino acid containing stereoisomer of the Pseudomonas aeruginosa biofilm inhibitor FD2. D-FD2 showed lower affinity for the fucose specific lectin LecB, was also active as a biofilm inhibitor and in addition showed high stability towards proteolysis with pure proteases and in human serum.

Graphical abstract: Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

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Publication details

The article was received on 22 Dec 2010, accepted on 14 Feb 2011 and first published on 10 Mar 2011


Article type: Concise Article
DOI: 10.1039/C0MD00270D
Citation: Med. Chem. Commun., 2011,2, 418-420
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    Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

    E. M. V. Johansson, R. U. Kadam, G. Rispoli, S. A. Crusz, K. Bartels, S. P. Diggle, M. Cámara, P. Williams, K. Jaeger, T. Darbre and J. Reymond, Med. Chem. Commun., 2011, 2, 418
    DOI: 10.1039/C0MD00270D

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