Issue 5, 2011
From the journal:

MedChemComm

Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids†

Emma M. V. Johansson,a   Rameshwar U. Kadam,a   Gabriele Rispoli,a   Shanika A. Crusz,b   Kai-Malte Bartels,c   Stephen P. Diggle,b   Miguel Cámara,b   Paul Williams,b   Karl-Erich Jaeger,c   Tamis Darbrea  and  Jean-Louis Reymond*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, Berne, Switzerland
E-mail: jean-louis.reymond@ioc.unibe.ch
Fax: +41 31 631 80 57
Tel: +41 31 631 43 25

b School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK

c Institute of Molecular Enzyme Technology, Heinrich-Heine-University of Duesseldorf, Research Centre Juelich, Juelich, Germany

Abstract

The C-fucosyl peptide dendrimer D-FD2 (CFuc-lys-pro-leu)4(Lys-phe-lys-leu)2Lys-his-leu-NH2 was prepared as the D-amino acid containing stereoisomer of the Pseudomonas aeruginosa biofilm inhibitor FD2. D-FD2 showed lower affinity for the fucose specific lectin LecB, was also active as a biofilm inhibitor and in addition showed high stability towards proteolysis with pure proteases and in human serum.

Graphical abstract: Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

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Article information

DOI
https://doi.org/10.1039/C0MD00270D
Article type
Concise Article
Submitted
22 Dec 2010
Accepted
14 Feb 2011
First published
10 Mar 2011

Med. Chem. Commun., 2011,2, 418-420

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Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids

E. M. V. Johansson, R. U. Kadam, G. Rispoli, S. A. Crusz, K. Bartels, S. P. Diggle, M. Cámara, P. Williams, K. Jaeger, T. Darbre and J. Reymond, Med. Chem. Commun., 2011, 2, 418 DOI: 10.1039/C0MD00270D

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