Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Tuesday 19th September 2017 from 8.00am to 4.00pm (BST).

During this time our website performance may be temporarily affected. If you have any questions please use the feedback button available under our menu button. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 4, 2011
Previous Article Next Article

Erythromycin B: conformational analysis and antibacterial activity

Author affiliations


Erythromycin B, an acid-stable co-metabolite of the important antibiotic erythromycin A, differs from erythromycin A only in the absence of a hydroxyl group at C12, yet it has never been licensed for clinical use. We describe an NMR-based analysis of the conformation of erythromycin B, both free in aqueous solution and when weakly bound to bacterial ribosomes and show that it is conformationally similar to erythromycin A. The antibacterial activity of erythromycin B is shown to be similar to that of erythromycin A, but after acid-treatment, resembling exposure to the stomach, erythromycin B substantially retains antibacterial activity, whereas erythromycin A does not.

Graphical abstract: Erythromycin B: conformational analysis and antibacterial activity

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Dec 2010, accepted on 11 Feb 2011 and first published on 03 Mar 2011

Article type: Concise Article
DOI: 10.1039/C0MD00251H
Citation: Med. Chem. Commun., 2011,2, 331-336
  •   Request permissions

    Erythromycin B: conformational analysis and antibacterial activity

    P. Tyson, A. Hassanzadeh, Mohd. N. Mordi, D. G. Allison, V. Marquez and J. Barber, Med. Chem. Commun., 2011, 2, 331
    DOI: 10.1039/C0MD00251H

Search articles by author