Jump to main content
Jump to site search

Issue 5, 2011
Previous Article Next Article

Synthesis, in silico screening and bioevaluation of dispiro-cycloalkanones as antitubercular and mycobacterial NAD+-dependent DNA ligase inhibitors

Author affiliations

Abstract

A series of dispiro-cycloalkanones were synthesized using the “Corey Chaykovsky” reaction of α,α′-(E,E)-bis(benzylidene)-cycloalkanones/methanone in good yields. The compounds were evaluated for their in vitro antituberculosis activity against M. tuberculosis H37Rv and screened in silico. Some selected compounds were screened for mycobacterial NAD+-dependent DNA ligase inhibitory activity. Two of the compounds showed good in vitro antitubercular and NAD+-dependent DNA ligase inhibitory activity along with good correlation to in silico results.

Graphical abstract: Synthesis, in silico screening and bioevaluation of dispiro-cycloalkanones as antitubercular and mycobacterial NAD+-dependent DNA ligase inhibitors

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Dec 2010, accepted on 21 Jan 2011 and first published on 28 Feb 2011


Article type: Concise Article
DOI: 10.1039/C0MD00246A
Citation: Med. Chem. Commun., 2011,2, 378-384
  •   Request permissions

    Synthesis, in silico screening and bioevaluation of dispiro-cycloalkanones as antitubercular and mycobacterial NAD+-dependent DNA ligase inhibitors

    R. P. Tripathi, J. Pandey, V. Kukshal, A. Ajay, M. Mishra, D. Dube, D. Chopra, R. Dwivedi, V. Chaturvedi and R. Ramachandran, Med. Chem. Commun., 2011, 2, 378
    DOI: 10.1039/C0MD00246A

Search articles by author

Spotlight

Advertisements