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Issue 2, 2011
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New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles

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Abstract

A bifunctional chelator featuring (DO3A-AM)-Porphyrin units has been prepared. The high-field relaxivity of the Gd complex is similar to those of currently available contrast agents clearly showing that the first coordination sphere remains identical to the parent molecule [Gd(DO3A-AM)(H2O)], with one coordinated water molecule.

Graphical abstract: New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles

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Publication details

The article was received on 05 Nov 2010, accepted on 14 Nov 2010 and first published on 06 Dec 2010


Article type: Concise Article
DOI: 10.1039/C0MD00205D
Citation: Med. Chem. Commun., 2011,2, 119-125
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    New potential bimodal imaging contrast agents based on DOTA-like and porphyrin macrocycles

    C. P. Gros, A. Eggenspiller, A. Nonat, J. Barbe and F. Denat, Med. Chem. Commun., 2011, 2, 119
    DOI: 10.1039/C0MD00205D

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