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Issue 1, 2011
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Discovery of a novel benzopyranyl compound as a potent in vitro and in vivo osteogenic agent

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Abstract

A novel osteogenic agent containing a benzopyranyl core skeleton was discovered from cell-based alkaline phosphatase (ALP) assay of a small-molecule library constructed by diversity-oriented synthetic approach. The subsequent structure–activity relationship study using ALP and TOPflash reporter gene assay confirmed 6b as an osteogenesis activator. In in vivo study, we successfully demonstrated that the oral treatment of ovariectomized mice with 6b resulted in increased bone mass and bone volume as well as improved bone quality.

Graphical abstract: Discovery of a novel benzopyranyl compound as a potent in vitro and in vivo osteogenic agent

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Publication details

The article was received on 02 Sep 2010, accepted on 08 Oct 2010 and first published on 01 Nov 2010


Article type: Concise Article
DOI: 10.1039/C0MD00149J
Citation: Med. Chem. Commun., 2011,2, 76-80
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    Discovery of a novel benzopyranyl compound as a potent in vitro and in vivo osteogenic agent

    S. Oh, S. W. Cho, J. Yang, H. J. Sun, Y. S. Chung, C. S. Shin and S. B. Park, Med. Chem. Commun., 2011, 2, 76
    DOI: 10.1039/C0MD00149J

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