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Issue 7, 2011
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Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats

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Abstract

Rice is one of the most important staple foods in the world. The Cry2Agene was inserted into the rice genome to help the plant combat insects. As the unintended effects of the genetically modified (GM) organisms are the most important barriers to the promotion of GM organisms, we have carried out a useful exploration to establish a new in vivo evaluation model for genetically modified foods by metabonomics methods. In this study, the rats were fed for 90 days with the GM and NON-GM rice diets. The changes in metabolites of the urine were detected using 1H-NMR. The metabonomics were analyzed to see whether the GM rice can induce the metabolite changes in the rats’ urine when compared with the NON-GM rice group. The multivariate analysis and ANOVA were used to determine the differences and the significance of differences respectively, and eventually we concluded that these differences did not have a biological significance. The conclusion of the metabonomics was comparable with that from the traditional method. As a non-invasive and dynamic monitoring method, metabonomics will be a new way of assessing the food safety of GM foods.

Graphical abstract: Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats

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Publication details

The article was received on 25 Feb 2011, accepted on 06 Apr 2011 and first published on 19 May 2011


Article type: Paper
DOI: 10.1039/C1MB05076A
Citation: Mol. BioSyst., 2011,7, 2304-2310
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    Metabonomics study of transgenic Bacillus thuringiensis rice (T2A-1) meal in a 90-day dietary toxicity study in rats

    S. Cao, W. Xu, Y. Luo, X. He, Y. Yuan, W. Ran, L. Liang and K. Huang, Mol. BioSyst., 2011, 7, 2304
    DOI: 10.1039/C1MB05076A

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