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Issue 4, 2011
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Zinc-induced dimerization of the amyloid-β metal-binding domain 1–16 is mediated by residues 11–14

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Abstract

Analysis of complex formation between amyloid-β fragments using surface plasmon resonance biosensing and electrospray mass spectrometry reveals that region 11–14 mediates zinc-induced dimerization of amyloid-β and may serve as a potential drug target for preventing development and progression of Alzheimer's disease.

Graphical abstract: Zinc-induced dimerization of the amyloid-β metal-binding domain 1–16 is mediated by residues 11–14

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Publication details

The article was received on 16 Dec 2010, accepted on 01 Feb 2011 and first published on 25 Feb 2011


Article type: Communication
DOI: 10.1039/C0MB00334D
Citation: Mol. BioSyst., 2011,7, 1053-1055
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    Zinc-induced dimerization of the amyloid-β metal-binding domain 1–16 is mediated by residues 11–14

    S. A. Kozin, Y. V. Mezentsev, A. A. Kulikova, M. I. Indeykina, A. V. Golovin, A. S. Ivanov, P. O. Tsvetkov and A. A. Makarov, Mol. BioSyst., 2011, 7, 1053
    DOI: 10.1039/C0MB00334D

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