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Issue 4, 2011
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Non-telomeric activities of telomerase

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Abstract

Recent results suggest that telomerase is involved in many more cellular processes than merely telomere elongation. These include telomere-independent anti-apoptotic, cytoprotective and pro-proliferative effects of telomerase or protection of mitochondrial DNA against oxidative stress. Telomerase also participates in DNA repair and its essential subunits, hTR and hTERT, are able to modulate independently the cell's response to DNA damage. Recent high throughput analyses of gene expression showed that hTERT expression modulates expression of about 300 genes, including genes involved in the regulation of cell cycle progression, proliferation and differentiation. Besides the well-known telomerase catalytic activity of RNA-dependent DNA polymerase, its RNA-dependent RNA polymerase activity was recently described in association with the RNA subunit of mitochondrial RNA processing endoribonuclease, thus suggesting involvement of telomerase in RNA interference processes. These recent discoveries open novel possibilities and entirely unexpected research perspectives, branching off from the mainstream telomere and telomerase research.

Graphical abstract: Non-telomeric activities of telomerase

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Publication details

The article was received on 08 Nov 2010, accepted on 06 Jan 2011 and first published on 01 Feb 2011


Article type: Review Article
DOI: 10.1039/C0MB00268B
Citation: Mol. BioSyst., 2011,7, 1013-1023
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    Non-telomeric activities of telomerase

    J. Majerská, E. Sýkorová and J. Fajkus, Mol. BioSyst., 2011, 7, 1013
    DOI: 10.1039/C0MB00268B

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