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Issue 3, 2011
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Potential biomarkers in the urine of myocardial infarction rats: a metabolomic method and its application

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Abstract

A metabolomic method using reversed-phase liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) was developed to obtain a systematic view of the development and progression of myocardial infarction (MI). By combining with partial least squares discriminant analysis (PLS-DA), 16 biomarkers in rat urine were identified and eight of them were related to the pathway of energy metabolism. Among the regulated pathways, the citric acid cycle related network was acutely perturbed. The metabolomic results not only supplied a systematic view of the development and progression of MI but also provided the theoretical basis for the prevention or treatment of MI. The developed method was also used to analyze the therapeutic effects of a traditional Chinese medicine (TCM) named Shexiang Baoxin Pill (SBP), a widely used anti-MI medicine in clinics. The results showed that SBP administration could provide satisfactory effects on MI through partially regulating the perturbed pathway of energy metabolism.

Graphical abstract: Potential biomarkers in the urine of myocardial infarction rats: a metabolomic method and its application

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Publication details

The article was received on 22 Jul 2010, accepted on 10 Nov 2010 and first published on 10 Dec 2010


Article type: Paper
DOI: 10.1039/C0MB00110D
Citation: Mol. BioSyst., 2011,7, 824-831
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    Potential biomarkers in the urine of myocardial infarction rats: a metabolomic method and its application

    P. Jiang, W. Dai, S. Yan, Z. Chen, R. Xu, J. Ding, L. Xiang, S. Wang, R. Liu and W. Zhang, Mol. BioSyst., 2011, 7, 824
    DOI: 10.1039/C0MB00110D

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