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Issue 1, 2011
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Towards proteomics-on-chip: The role of the surface

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Miniaturisation is revolutionary to high-throughput proteomics. These technologies have gained much interest in the past decade, as they allow for sensitive parallel analysis of small amounts of biological materials. This review describes the state of the art of proteomics-on-chip, with a particular focus on the fundamental proteomics-on-chip challenges. The important role of bio-interfacial interactions and strategies to control them are presented. Various coating methodologies for on-chip protein/peptide separation are reviewed to provide an overview of the principles of protein-resistant and protein immobilisation coatings, and their effectiveness.

Graphical abstract: Towards proteomics-on-chip: The role of the surface

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The article was received on 28 Apr 2010, accepted on 29 Jun 2010 and first published on 12 Aug 2010

Article type: Review Article
DOI: 10.1039/C005236A
Citation: Mol. BioSyst., 2011,7, 101-115
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    Towards proteomics-on-chip: The role of the surface

    M. Salim, S. L. McArthur, S. Vaidyanathan and P. C. Wright, Mol. BioSyst., 2011, 7, 101
    DOI: 10.1039/C005236A

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