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Issue 15, 2011
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In situ dynamic measurements of the enhanced SERS signal using an optoelectrofluidic SERS platform

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Abstract

A novel active surface-enhanced Raman scattering (SERS) platform for dynamic on-demand generation of SERS active sites based on optoelectrofluidics is presented in this paper. When a laser source is projected into a sample solution containing metal nanoparticles in an optoelectrofluidic device and an alternating current (ac) electric field is applied, the metal nanoparticles are spontaneously concentrated and assembled within the laser spot, form SERS-active sites, and enhance the Raman signal significantly, allowing dynamic and more sensitive SERS detection. In this simple platform, in which a glass slide-like optoelectrofluidic device is integrated into a conventional SERS detection system, both dynamic concentration of metal nanoparticles and in situdetection of SERS signal are simultaneously possible with only a single laser source. This optoelectrofluidic SERS spectroscopy allows on-demand generation of ‘hot spots’ at specific regions of interest, and highly sensitive, reliable, and stable SERS measurements of the target molecules in a tiny volume (∼500 nL) of liquid sample without any fluidic components and complicated systems.

Graphical abstract: In situ dynamic measurements of the enhanced SERS signal using an optoelectrofluidic SERS platform

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Publication details

The article was received on 01 Apr 2011, accepted on 17 May 2011 and first published on 15 Jun 2011


Article type: Paper
DOI: 10.1039/C1LC20277D
Citation: Lab Chip, 2011,11, 2518-2525
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    In situ dynamic measurements of the enhanced SERS signal using an optoelectrofluidic SERS platform

    H. Hwang, D. Han, Y. Oh, Y. Cho, K. Jeong and J. Park, Lab Chip, 2011, 11, 2518
    DOI: 10.1039/C1LC20277D

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