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Issue 12, 2011
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Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads

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Abstract

We demonstrate a three-step assay on a silicon photonic microring resonator-based detection platform that enables the quantitation of the cardiac biomarker C-reactive protein (CRP) over a dynamic range spanning six orders of magnitude. Using antibody-modified microrings, we sequentially monitor primary CRP binding, secondary recognition of bound CRP by a biotinylated antibody, and tertiary signal amplification using streptavidin-functionalized beads. This detection methodology is applied to CRP quantitation in human serum and plasma samples.

Graphical abstract: Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads

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Publication details

The article was received on 15 Mar 2011, accepted on 14 Apr 2011 and first published on 04 May 2011


Article type: Communication
DOI: 10.1039/C1LC20231F
Citation: Lab Chip, 2011,11, 2042-2044
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    Sensitive on-chip detection of a protein biomarker in human serum and plasma over an extended dynamic range using silicon photonic microring resonators and sub-micron beads

    M. S. Luchansky, A. L. Washburn, M. S. McClellan and R. C. Bailey, Lab Chip, 2011, 11, 2042
    DOI: 10.1039/C1LC20231F

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