Issue 7, 2011
From the journal:

Lab on a Chip

Integrated systems for rapid point of care (PoC) blood cell analysis†

Cees van Berkel,a   James D. Gwyer,a   Steve Deane,a   Nicolas Green,b   Judith Holloway,c   Veronica Hollisb  and  Hywel Morgan*b  

* Corresponding authors

a Philips Research Laboratories, 101 Cambridge Science Park, Milton Road, Cambridge, UK

b School of Electronics and Computing Science, University of Southampton, Highfield, Southampton, UK
E-mail: hm@ecs.soton.ac.uk
Fax: +44(0)2380 593029
Tel: +44(0)2380 593330

c Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK

Abstract

Counting the different subpopulations of cells in a fingerprick of human blood is important for a number of clinical point-of-care (PoC) applications. It is a challenge to demonstrate the integration of sample preparation and detection techniques in a single platform. In this paper we demonstrate a generic microfluidic platform that combines sample processing and characterisation and enumeration in a single, integrated system. Results of microfluidic 3-part differential leukocyte (granulocyte, lymphocyte and monocyte) counts, together with erythrocyte and thrombocyte (platelet) counts, in human blood are shown and corroborated with results from hospital clinical laboratory analysis.

Graphical abstract: Integrated systems for rapid point of care (PoC) blood cell analysis

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Article information

DOI
https://doi.org/10.1039/C0LC00587H
Article type
Paper
Submitted
11 Nov 2010
Accepted
20 Jan 2011
First published
17 Feb 2011

Lab Chip, 2011,11, 1249-1255

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Integrated systems for rapid point of care (PoC) blood cell analysis

C. van Berkel, J. D. Gwyer, S. Deane, N. Green, J. Holloway, V. Hollis and H. Morgan, Lab Chip, 2011, 11, 1249 DOI: 10.1039/C0LC00587H

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