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Issue 7, 2011
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Multiplexed inkjet functionalization of silicon photonic biosensors

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The transformative potential of silicon photonics for chip-scale biosensing is limited primarily by the inability to selectively functionalize and exploit the extraordinary density of integrated optical devices on this platform. Silicon biosensors, such as the microring resonator, can be routinely fabricated to occupy a footprint of less than 50 × 50 µm; however, chemically addressing individual devices has proven to be a significant challenge due to their small size and alignment requirements. Herein, we describe a non-contact piezoelectric (inkjet) method for the rapid and efficient printing of bioactive proteins, glycoproteins and neoglycoconjugates onto a high-density silicon microring resonator biosensor array. This approach demonstrates the scalable fabrication of multiplexed silicon photonic biosensors for lab-on-a-chip applications, and is further applicable to the functionalization of any semiconductor-based biosensor chip.

Graphical abstract: Multiplexed inkjet functionalization of silicon photonic biosensors

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Publication details

The article was received on 18 Aug 2010, accepted on 26 Jan 2011 and first published on 15 Feb 2011

Article type: Technical Note
DOI: 10.1039/C0LC00313A
Citation: Lab Chip, 2011,11, 1372-1377
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    Multiplexed inkjet functionalization of silicon photonic biosensors

    J. T. Kirk, G. E. Fridley, J. W. Chamberlain, E. D. Christensen, M. Hochberg and D. M. Ratner, Lab Chip, 2011, 11, 1372
    DOI: 10.1039/C0LC00313A

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