Jump to main content
Jump to site search

Issue 1, 2011
Previous Article Next Article

Aptamer sandwich-based carbon nanotube sensors for single-carbon-atomic-resolution detection ofnon-polar small molecular species

Author affiliations

Abstract

A portable sensor platform for the detection of small molecular species is crucial for the on-site monitoring of environmental pollutants, food toxicants, and disease-related metabolites. However, it is still extremely difficult to find highly selective and sensitive sensor platforms for general small molecular detection. Herein, we report aptamer sandwich-based carbon nanotube sensor strategy for small molecular detection, where aptamers were utilized to capture target molecules as well as to enhance the sensor signals. We successfully demonstrated the detection of non-polar bisphenol A molecules with a 1 pM sensitivity. Significantly, our sensors were able to distinguish between similar small molecular species with single-carbon-atomic resolution. Furthermore, using the additional biotin modification on labeling aptamer, we enhanced the detection limit of our sensors down to 10 fM. This strategy allowed us to detect non-polar small molecular species using carbon nanotube transistors, thus overcoming the fundamental limitation of field effect transistor-based sensors. Considering the extensive applications of sandwich assay for the detection of rather large biomolecules, our results should open up completely new dimension in small molecular detection technology and should enable a broad range of applications such as environmental protection and food safety.

Graphical abstract: Aptamer sandwich-based carbon nanotube sensors for single-carbon-atomic-resolution detection ofnon-polar small molecular species

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 30 Jul 2010, accepted on 28 Sep 2010 and first published on 22 Oct 2010


Article type: Paper
DOI: 10.1039/C0LC00259C
Citation: Lab Chip, 2011,11, 52-56
  •   Request permissions

    Aptamer sandwich-based carbon nanotube sensors for single-carbon-atomic-resolution detection ofnon-polar small molecular species

    J. Lee, M. Jo, T. H. Kim, J. Ahn, D. Lee, S. Kim and S. Hong, Lab Chip, 2011, 11, 52
    DOI: 10.1039/C0LC00259C

Search articles by author