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Issue 7, 2011
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Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array

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Abstract

We report a portable lensless on-chip microscope that can achieve <1 µm resolution over a wide field-of-view of ∼24 mm2 without the use of any mechanical scanning. This compact on-chip microscope weighs ∼95 g and is based on partially coherent digital in-line holography. Multiple fiber-optic waveguides are butt-coupled to light emitting diodes, which are controlled by a low-cost micro-controller to sequentially illuminate the sample. The resulting lensfree holograms are then captured by a digital sensor-array and are rapidly processed using a pixel super-resolution algorithm to generate much higher resolution holographic images (both phase and amplitude) of the objects. This wide-field and high-resolution on-chip microscope, being compact and light-weight, would be important for global health problems such as diagnosis of infectious diseases in remote locations. Toward this end, we validate the performance of this field-portable microscope by imaging human malaria parasites (Plasmodium falciparum) in thin blood smears. Our results constitute the first-time that a lensfree on-chip microscope has successfully imaged malaria parasites.

Graphical abstract: Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array

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Publication details

The article was received on 11 Dec 2010, accepted on 16 Feb 2011 and first published on 01 Mar 2011


Article type: Communication
DOI: 10.1039/C0LC00684J
Citation: Lab Chip, 2011,11, 1276-1279
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    Holographic pixel super-resolution in portable lensless on-chip microscopy using a fiber-optic array

    W. Bishara, U. Sikora, O. Mudanyali, T. Su, O. Yaglidere, S. Luckhart and A. Ozcan, Lab Chip, 2011, 11, 1276
    DOI: 10.1039/C0LC00684J

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