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Issue 5, 2011
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Tailorable integrated optofluidic filters for biomolecular detection

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Abstract

Spectral filtering is an essential component of biophotonic methods such as fluorescence and Raman spectroscopy. Predominantly utilized in bulk microscopy, filters require efficient and selective transmission or removal of signals at one or more wavelength bands. However, towards highly sensitive and fully self-contained lab-on-chip systems, the integration of spectral filters is an essential step. In this work, a novel optofluidic solution is presented in which a liquid-core optical waveguide both transports sample analytes and acts as an efficient filter for advanced spectroscopy. To this end, the wavelength dependent nature of interference-based antiresonant reflecting optical waveguide technology is exploited. An extinction of 37 dB, a narrow rejection band of only 2.5 nm and a free spectral range of 76 nm using three specifically designed dielectric layers are demonstrated. These parameters result in an 18.4-fold increase in the signal-to-noise ratio for on-chip fluorescence detection. In addition, liquid-core waveguide filters with three operating wavelengths were designed for Förster resonance energy transfer detection and demonstrated using doubly labeled oligonucleotides. Incorporation of high-performance spectral processing illustrates the power of the optofluidic concept where fluidic channels also perform optical functions to create innovative and highly integrated lab-on-chip devices.

Graphical abstract: Tailorable integrated optofluidic filters for biomolecular detection

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Publication details

The article was received on 12 Oct 2010, accepted on 14 Dec 2010 and first published on 10 Jan 2011


Article type: Paper
DOI: 10.1039/C0LC00496K
Citation: Lab Chip, 2011,11, 899-904
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    Tailorable integrated optofluidic filters for biomolecular detection

    P. Measor, B. S. Phillips, A. Chen, A. R. Hawkins and H. Schmidt, Lab Chip, 2011, 11, 899
    DOI: 10.1039/C0LC00496K

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