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Issue 26, 2011
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Highly stable, amphiphilic DNA-encoded nanoparticle conjugates for DNA encoding/decoding applications

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Abstract

We synthesized highly stable, amphiphilic polymer-protected DNA–Au nanoparticle conjugates (DNA–AuNPs) and developed a DNA encoding/decoding strategy using these particles. Here, DNA–AuNPs were encapsulated by amphiphilic poly(N-vinyl-2-pyrrolidone) (PVP) to make them more stable and soluble in both organic and aqueous solvents. These particles are stable in a wide range of salt concentrations, pH and temperatures and sustain their stability even after the addition of D,L-dithiothreitol. Finally, this polymer layer was readily removed and particle-modified DNA was decoded via the microarrayed chip and dark-field-based AuNP imaging technique.

Graphical abstract: Highly stable, amphiphilic DNA-encoded nanoparticle conjugates for DNA encoding/decoding applications

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Publication details

The article was received on 17 Mar 2011, accepted on 10 May 2011 and first published on 02 Jun 2011


Article type: Communication
DOI: 10.1039/C1JM11150G
Citation: J. Mater. Chem., 2011,21, 9467-9470
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    Highly stable, amphiphilic DNA-encoded nanoparticle conjugates for DNA encoding/decoding applications

    D. Lim, M. Cui and J. Nam, J. Mater. Chem., 2011, 21, 9467
    DOI: 10.1039/C1JM11150G

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