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Issue 29, 2011
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Fabrication, microstructure, and BMP-2 delivery of novel biodegradable and biocompatible silicate–collagen hybrid fibril sheets

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Abstract

Silicate–collagen hybrid fibril sheets were obtained using 3-glycidoxypropyl trimethoxysilane (GPTMS) as a novel cross-linker for type I collagen fibrils. BMP-2 was introduced in the hybrid sheets to stimulate cell proliferation and differentiation. Scanning electron microscopy images indicated that the resultant sheets were nanofibrous and porous. Transmission electron microscopy images showed that each hybrid fibril maintained a typical periodic unit of 60–70 nm. Compared to fibrils cross-linked by a conventional carbodiimide agent, the present hybrid fibrils were much more resistant against type I collagenase degradation. When soaked in BMP-2 solution, the hybrid sheets easily adsorbed BMP-2 and exhibited sustained release for BMP-2. Osteoblast-like MC3T3-E1 cells were well attached to and proliferated on the hybrid sheets. The proliferation and differentiation of these cells were enhanced to form collagen fibrils due to BMP-2 release.

Graphical abstract: Fabrication, microstructure, and BMP-2 delivery of novel biodegradable and biocompatible silicate–collagen hybrid fibril sheets

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Publication details

The article was received on 25 Feb 2011, accepted on 10 May 2011 and first published on 03 Jun 2011


Article type: Paper
DOI: 10.1039/C1JM10829H
Citation: J. Mater. Chem., 2011,21, 10942-10948
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    Fabrication, microstructure, and BMP-2 delivery of novel biodegradable and biocompatible silicate–collagen hybrid fibril sheets

    S. Chen, A. Osaka, T. Ikoma, H. Morita, J. Li, M. Takeguchi and N. Hanagata, J. Mater. Chem., 2011, 21, 10942
    DOI: 10.1039/C1JM10829H

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