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Issue 12, 2011
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Carbon nanospheres for fluorescent biomolecular detection

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In this article, we demonstrate the facile preparation of carbon nanospheres on a large scale by treating graphite with chlorosulfonic acid and their use as very effective quenchers for highly sensitive and selective nucleic acid and thrombin detection. The detection is accomplished by two steps: (1) a carbon nanosphere (CNS) adsorbs and quenches the fluorescence of a dye-labeled single-stranded DNA (ssDNA) probe; (2) in the presence of a target, the biomolecular mutual interaction suppresses fluorescence quenching, which makes the ssDNA detach from the CNS surface, leading to recovery of the dye fluorescence.

Graphical abstract: Carbon nanospheres for fluorescent biomolecular detection

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The article was received on 26 Nov 2010, accepted on 17 Jan 2011 and first published on 11 Feb 2011

Article type: Paper
DOI: 10.1039/C0JM04107F
Citation: J. Mater. Chem., 2011,21, 4663-4668
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    Carbon nanospheres for fluorescent biomolecular detection

    H. Li, Y. Zhang, T. Wu, S. Liu, L. Wang and X. Sun, J. Mater. Chem., 2011, 21, 4663
    DOI: 10.1039/C0JM04107F

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