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Issue 9, 2011
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Dual-vectors of anti-cancer drugs and genes based on pH-sensitive micelles self-assembled from hybrid polypeptide copolymers

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Abstract

A series of amphiphilic pH-sensitive hybrid polypeptide copolymers, poly(ethylene glycol)-b-poly(L-lysine)-b-poly(L-phenylalanine) (PEG-PLL-PLP) were synthesized. The copolymers could self-assemble into micelles with PLP as the hydrophobic core and PEG-PLL as the hydrophilic shell, as evidenced by 1HNMR and TEM. These micelles exhibited obvious pH response in hydrodynamic diameter and pH-dependent drug release behavior, attributed to the protonation/deprotonation of amino groups in PLL segments. The copolymers could further condense plasmid DNA efficiently. Importantly, the polymer/DNA complexes showed high transfection efficiency in 293T cells under optimized conditions. This study suggested the copolymers may have great potential in both drug and gene delivery.

Graphical abstract: Dual-vectors of anti-cancer drugs and genes based on pH-sensitive micelles self-assembled from hybrid polypeptide copolymers

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Publication details

The article was received on 08 Oct 2010, accepted on 30 Nov 2010 and first published on 24 Jan 2011


Article type: Paper
DOI: 10.1039/C0JM03385E
Citation: J. Mater. Chem., 2011,21, 3100-3106
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    Dual-vectors of anti-cancer drugs and genes based on pH-sensitive micelles self-assembled from hybrid polypeptide copolymers

    Y. Li, S. Hua, W. Xiao, H. Wang, X. Luo, C. Li, S. Cheng, X. Zhang and R. Zhuo, J. Mater. Chem., 2011, 21, 3100
    DOI: 10.1039/C0JM03385E

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