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Issue 9, 2011
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Hollow chitosansilica nanospheres for doxorubicin delivery to cancer cells with enhanced antitumor effect in vivo

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Abstract

Here we report the synthesis of hybrid hollow chitosansilica nanospheres (CS–Silica NPs) with chitosan–polyacrylic acid (CS–PAA) nanoparticles as the template and doxorubicin (DOX) delivery based on CS–Silica NPs. The morphology and the microstructure of CS–Silica NPs were characterized by field emission scanning electron microscopy (FESEM) and X-ray photoelectron spectroscopy (XPS). The confocal laser scanning microscopy (CLSM) and flow cytometry experiments showed that the cellular uptake of the DOX-loaded CS–Silica NPs was time dependent. In addition, cellular internalization and intracellular distribution of DOX-loaded CS–Silica NPs indicated that the DOX was mainly distributed in the cell nucleus while the carriers were primarily located in the cytoplasm. In vivo antitumor response indicated that the DOX loaded CS–Silica hybrid hollow nanospheres exhibited superior antitumor effect over the free drugin vivo, which might be ascribable to the enhanced cellular uptake efficiency and the effective delivery of drug to the cell nucleus.

Graphical abstract: Hollow chitosan–silica nanospheres for doxorubicin delivery to cancer cells with enhanced antitumor effect in vivo

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Publication details

The article was received on 27 Sep 2010, accepted on 22 Nov 2010 and first published on 24 Jan 2011


Article type: Paper
DOI: 10.1039/C0JM03234D
Citation: J. Mater. Chem., 2011,21, 3147-3155
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    Hollow chitosansilica nanospheres for doxorubicin delivery to cancer cells with enhanced antitumor effect in vivo

    E. Yan, Y. Fu, X. Wang, Y. Ding, H. Qian, C. Wang, Y. Hu and X. Jiang, J. Mater. Chem., 2011, 21, 3147
    DOI: 10.1039/C0JM03234D

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