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Issue 9, 2011
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NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles

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Abstract

In this paper we describe the synthesis and the optimisation of a new family of fluorescent core–shell nanoparticle using protein-stabilised gold nanoclusters. Fluorescent gold nanoclusters (<2 nm) entrapped in bovine serum albumin (BSA) protein were loaded in a 100 nm-silica nanoparticle with an optimal concentration of 3% (w/w). These nanoparticles kept the fluorescence properties of the metal clusters with a high Stokes shift and an emission in the near infrared region (λ = 670 nm). They were fully characterized and showed a high monodispersity and stability over more than 5 months. Steady-state fluorescence and lifetime measurements indicate the role of silica as a protective host to improve the photostability and the chemical stability of the fluorescent compound. This new label was taken up in tumor lung cells and tracked by a confocal microscope to show the great potential of this biolabel for sensing and imaging.

Graphical abstract: NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles

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Publication details

The article was received on 13 Aug 2010, accepted on 13 Dec 2010 and first published on 24 Jan 2011


Article type: Paper
DOI: 10.1039/C0JM02660C
Citation: J. Mater. Chem., 2011,21, 2974-2981
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    NIR-emitting fluorescent gold nanoclusters doped in silica nanoparticles

    X. Le Guével, B. Hötzer, G. Jung and M. Schneider, J. Mater. Chem., 2011, 21, 2974
    DOI: 10.1039/C0JM02660C

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