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Issue 20, 2011
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Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity

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Abstract

Apoferritin-encapsulated Pt nanoparticles (AFt–Pt) were bio-mimetically prepared by an in situreduction method in the unique 8 nm spherical cage of apoferritin. The average size of AFt–Pt was 4.3 ± 0.9 nm. The spherical structure of apoferritin remained intact after loading Pt particles in its cavity. Apoferritin coating increased the amount of Pt internalized in HepG2 cells by about three times viareceptor-mediated endocytosis. AFt–Pt showed greatly improved biocompatibility compared with polyvinylpyrrolidone stabilized Pt nanoparticles (PVP–Pt). More than 80% of cells survived after treatment with 100 μM AFt–Pt for 48 h. By camouflaging the particles with a protein corona, apoferritin conferred a cell-recognizable identity to the particles, which strikingly ameliorated the bio-effects of the nanoparticles.

Graphical abstract: Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity

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Publication details

The article was received on 08 Feb 2011, accepted on 15 Mar 2011 and first published on 07 Apr 2011


Article type: Paper
DOI: 10.1039/C1JM10575B
Citation: J. Mater. Chem., 2011,21, 7105-7110
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    Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity

    X. Liu, W. Wei, C. Wang, H. Yue, D. Ma, C. Zhu, G. Ma and Y. Du, J. Mater. Chem., 2011, 21, 7105
    DOI: 10.1039/C1JM10575B

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