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Issue 20, 2011
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Materials for central nervous system regeneration: bioactive cues

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Abstract

Current clinical therapies have limited capacity to restore function in damaged nerves. Regeneration of axons in the injured central nervous system is inhibited by the presence of both physical and mechanical barriers. As such, neural tissue engineering strategies have received considerable attention in recent years. Materials-based approaches offer a way to blend synthetic and biological components in order to generate environments conducive to neural regeneration. While biomaterials themselves can facilitate regeneration simply by providing a substrate for cell growth, incorporation of “bioactive cues”—or molecules which interact with cells to elicit a specific response—has become increasingly necessary in order to promote nerve regeneration. This review attempts to outline the various biomaterials that are promising for central nerve applications, and discusses the array of bioactive cues that are valuable in promoting nerve repair.

Graphical abstract: Materials for central nervous system regeneration: bioactive cues

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Publication details

The article was received on 11 Dec 2010, accepted on 28 Feb 2011 and first published on 31 Mar 2011


Article type: Application
DOI: 10.1039/C0JM04335D
Citation: J. Mater. Chem., 2011,21, 7033-7051
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    Materials for central nervous system regeneration: bioactive cues

    C. Gumera, B. Rauck and Y. Wang, J. Mater. Chem., 2011, 21, 7033
    DOI: 10.1039/C0JM04335D

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