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Issue 5, 2011
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Sequencing transcriptomes in toto

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The development of next-generation sequencing technologies has enabled the transcriptome to be measured and characterized at a level which was previously unattainable. Shot gun sequencing of RNAs, or RNA-Seq as it is known, is providing the means to simultaneously survey locus activity, transcript-specific expression, sequence content of transcripts and transcriptome discovery. This article discusses the current state of RNA-Seq, its potential for redefining transcriptomics and some of the challenges associated with this revolutionary technology.

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The article was received on 01 Jul 2010, accepted on 27 Dec 2010 and first published on 04 Feb 2011

Article type: Review Article
DOI: 10.1039/C0IB00062K
Citation: Integr. Biol., 2011,3, 522-528
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    Sequencing transcriptomes in toto

    K. S. Kassahn, N. Waddell and S. M. Grimmond, Integr. Biol., 2011, 3, 522
    DOI: 10.1039/C0IB00062K

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