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Issue 9, 2011
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Enzymatic synthesis of optical pure β-nitroalcohols by combining D-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution

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Abstract

An enzymatic method which combines D-aminoacylase catalyzed nitroaldol reaction and lipase PS-IM catalyzed acyl resolution reaction was constructed to obtain optically pure β-nitroalcohols in organic media under mild conditions. A series of β-nitroalcohols were synthesized and then resolved, with excellent ee values (>95%) and yields mostly, giving enantiomerically pure acetate and alcohol of the opposite configuration simultaneously.

Graphical abstract: Enzymatic synthesis of optical pure β-nitroalcohols by combining d-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution

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Publication details

The article was received on 15 Apr 2011, accepted on 23 Jun 2011 and first published on 18 Jul 2011


Article type: Communication
DOI: 10.1039/C1GC15417F
Citation: Green Chem., 2011,13, 2359-2361
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    Enzymatic synthesis of optical pure β-nitroalcohols by combining D-aminoacylase-catalyzed nitroaldol reaction and immobilized lipase PS-catalyzed kinetic resolution

    F. Xu, J. Wang, B. Liu, Q. Wu and X. Lin, Green Chem., 2011, 13, 2359
    DOI: 10.1039/C1GC15417F

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