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Issue 4, 2011
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Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

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Abstract

Solvents make a large contribution to the environmental impact of manufacturing processes of active pharmaceutical ingredients (API), as well as playing an important role in other chemical industries, with millions of tons used and disposed of each year. GlaxoSmithKline (GSK) has previously reported on the both the development of a GSK solvent selection guide and the incorporation of solvent life cycle inventory and assessment information. The GSK solvent selection guide has been further enhanced by:

• Revising the assessments of factors that impact process safety, separating reactivity from fire and explosion rankings.

• More than doubling the number of solvents in the guide, to a total of 110 from the initial 47.

• Adding a customised solvent selection guide appropriate for medicinal chemistry and analytical laboratories.

The new GSK solvent selection guide enables GSK scientists to objectively assess solvents and determine whether existing or new solvents brought to market as ‘greener’ alternatives truly represent a more sustainable choice or whether they are just addressing a single issue associated with sustainability.

Graphical abstract: Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

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Publication details

The article was received on 13 Dec 2010, accepted on 01 Feb 2011 and first published on 08 Mar 2011


Article type: Paper
DOI: 10.1039/C0GC00918K
Citation: Green Chem., 2011,13, 854-862
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    Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

    R. K. Henderson, C. Jiménez-González, D. J. C. Constable, S. R. Alston, G. G. A. Inglis, G. Fisher, J. Sherwood, S. P. Binks and A. D. Curzons, Green Chem., 2011, 13, 854
    DOI: 10.1039/C0GC00918K

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