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Issue 5, 2011
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The direct carboxylation of terminal alkynes with carbon dioxide

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Abstract

A simple and straight-forward method has been developed for direct carboxylation of terminal alkynes using CO2 as the C1 carbon feedstock. The direct C–H bond functionalization is achieved with Cs2CO3 as the base and in the absence of transition metal catalyst. Various propiolic acids were synthesized in good to excellent yields with a wide substrate scope and a good functional groups tolerance. This is a more atom- and step-economic protocol with great potential in practical application.

Graphical abstract: The direct carboxylation of terminal alkynes with carbon dioxide

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Publication details

The article was received on 16 Nov 2010, accepted on 28 Feb 2011 and first published on 22 Mar 2011


Article type: Paper
DOI: 10.1039/C0GC00819B
Citation: Green Chem., 2011,13, 1275-1279
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    The direct carboxylation of terminal alkynes with carbon dioxide

    Y. Dingyi and Z. Yugen, Green Chem., 2011, 13, 1275
    DOI: 10.1039/C0GC00819B

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