Jump to main content
Jump to site search

Issue 3, 2011
Previous Article Next Article

An environmentally benign approach for the synthesis of bifunctional sulfonamide-amide compounds viaisocyanide-based multicomponent reactions

Author affiliations

Abstract

Three-component reaction of the zwitterion generated from dialkyl acetylenedicarboxylate and an alkyl or aryl isocyanide with an alkyl or aryl sulfonamide is described. The reaction afforded the corresponding special type of ketenimine sulfonamide derivatives in water without using any activation and modification. The products could be easily hydrolyzed to the corresponding sulfonamide-butanamide derivatives at 80 °C in good yields without using a catalyst.

Graphical abstract: An environmentally benign approach for the synthesis of bifunctional sulfonamide-amide compounds viaisocyanide-based multicomponent reactions

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Aug 2010, accepted on 05 Jan 2011 and first published on 07 Feb 2011


Article type: Communication
DOI: 10.1039/C0GC00442A
Citation: Green Chem., 2011,13, 582-585
  •   Request permissions

    An environmentally benign approach for the synthesis of bifunctional sulfonamide-amide compounds viaisocyanide-based multicomponent reactions

    A. Shaabani, A. Sarvary, S. Ghasemi, A. H. Rezayan, R. Ghadari and S. W. Ng, Green Chem., 2011, 13, 582
    DOI: 10.1039/C0GC00442A

Search articles by author

Spotlight

Advertisements