Issue 11, 2011
From the journal:

Green Chemistry

Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural†

Mark Mascal*a  and  Saikat Duttaa  

* Corresponding authors

a Department of Chemistry, University of California Davis, 1 Shields Avenue, Davis, CA, US
E-mail: mascal@chem.ucdavis.edu
Fax: 530-752-8995
Tel: 530-754-5373

Abstract

The biomass-derived platform chemical 5-(chloromethyl)furfural is converted into the blockbuster antiulcer drug ranitidine (Zantac) in four steps with an overall 68% isolated yield.

Graphical abstract: Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1GC15537G
Article type
Communication
Submitted
11 May 2011
Accepted
29 Aug 2011
First published
19 Sep 2011

Green Chem., 2011,13, 3101-3102

Permissions

Request permissions

Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural

M. Mascal and S. Dutta, Green Chem., 2011, 13, 3101 DOI: 10.1039/C1GC15537G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements