Issue 5, 2011
From the journal:

Green Chemistry

Efficient “on water” organocatalytic protocol for the synthesis of optically pure warfarinanticoagulant

Maria Rogozińska,a   Anna Adamkiewiczb  and  Jacek Mlynarski*ab  

* Corresponding authors

a Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, Poland

b Faculty of Chemistry, Jagiellonian University, Ingardena 3, Krakow, Poland
E-mail: jacek.mlynarski@gmail.com
Fax: +48 12 663 2035

Abstract

The present development leads to an efficient protocol for the “on water” formation of one of the most widely used anticoagulants warfarin: the presented scalable and environmentally friendly organocatalytic approach affords the target drug in optically pure form.

Graphical abstract: Efficient “on water” organocatalytic protocol for the synthesis of optically pure warfarin anticoagulant

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Article information

DOI
https://doi.org/10.1039/C1GC15118E
Article type
Communication
Submitted
30 Jan 2011
Accepted
21 Mar 2011
First published
07 Apr 2011

Green Chem., 2011,13, 1155-1157

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Efficient “on water” organocatalytic protocol for the synthesis of optically pure warfarin anticoagulant

M. Rogozińska, A. Adamkiewicz and J. Mlynarski, Green Chem., 2011, 13, 1155 DOI: 10.1039/C1GC15118E

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