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Issue 1, 2011
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Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglyconein vivo

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Abstract

Quercetin is a typical anti-oxidative flavonoid ubiquitously distributed in vegetables. It is likely to act as a bioactive compound by exerting reactive oxygen species (ROS)-scavenging activity and/or binding to specific proteins such as oxidative enzymes and transcriptional factors in signal transduction pathways. Its absorption and metabolism (as well as its molecular targets) have been extensively explored from the viewpoint of its potential for disease prevention. It is known that glucuronide and/or sulfate conjugates with or without O-methylation exclusively circulate in the human bloodstream after intake of a quercetin-containing diet. We propose that glucuronide conjugates of quercetin function not only as detoxified metabolites but hydrophilic bioactive agents to various ROS-generating systems and precursors of hydrophobic aglycone. Quercetin aglycone is assumed to emerge in the target site by the action of β-glucuronidase activity under oxidative stress such as inflammation. The cardiovascular system and central nervous system seem to be the major targets of conjugated quercetin glucuronides circulating in the human bloodstream.

Graphical abstract: Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglyconein vivo

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Publication details

The article was received on 31 Jul 2010, accepted on 30 Sep 2010 and first published on 17 Nov 2010


Article type: Review Article
DOI: 10.1039/C0FO00106F
Citation: Food Funct., 2011,2, 11-17
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    Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglyconein vivo

    J. Terao, K. Murota and Y. Kawai, Food Funct., 2011, 2, 11
    DOI: 10.1039/C0FO00106F

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