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Volume 149, 2011
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Multi-modal molecular imaging approaches to detect primary cells in preclinical models

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Abstract

The need to understand cellular trafficking in vivo in situ requires the development and application of novel methodologies for cellular labeling and cell tracking. Here we applied new technologies associated with advances in molecular imaging to demonstrate the feasibility of labeling primary immune cells. We demonstrate the utility of fluorescently tagged polystyrene microspheres, MRI susceptible emulsions and cell entry peptoids. The adaptation of these labeling agents will permit cell specific delivery, diagnostic sensing and the delivery of therapeutic agents to sites of inflammation and infection.

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Publication details

The article was received on 01 Jun 2010, accepted on 05 Jul 2010 and first published on 15 Oct 2010


Article type: Paper
DOI: 10.1039/C005410K
Citation: Faraday Discuss., 2011,149, 107-114
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    Multi-modal molecular imaging approaches to detect primary cells in preclinical models

    K. Dhaliwal, L. Alexander, G. Escher, A. Unciti-Broceta, M. Jansen, N. Mcdonald, J. M. Cardenas-Maestre, R. Sanchez-Martin, J. Simpson, C. Haslett, and M. Bradley, Faraday Discuss., 2011, 149, 107
    DOI: 10.1039/C005410K

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