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Volume 149, 2011
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Multimodal superparamagnetic nanoplatform for clinical applications: immunoassays, imaging & therapy

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Abstract

A new type of multifunctional magnetic nano-platform for bioassays, diagnosis and therapy applications was designed using superparamagnetic γFe2O3 nanoparticles conjugated to hydroxylmethylene bisphosphonate (HMBPs) molecules. The nanoparticle has two essential roles: to act as a probe owing to its specific magnetic properties and to carry on its surface antitumoral molecules (therapeutic applications) or precursor groups for the covalent coupling of biological recognition molecules, such as antibodies, nucleic acids (in vitro & in vivo diagnosis).

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The article was received on 05 May 2010, accepted on 21 Jul 2010 and first published on 24 Sep 2010


Article type: Paper
DOI: 10.1039/C005286H
Citation: Faraday Discuss., 2011,149, 211-225
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    Multimodal superparamagnetic nanoplatform for clinical applications: immunoassays, imaging & therapy

    L. Motte, F. Benyettou, C. de Beaucorps, M. Lecouvey, I. Milesovic and Y. Lalatonne, Faraday Discuss., 2011, 149, 211
    DOI: 10.1039/C005286H

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