Jump to main content
Jump to site search

Issue 2, 2011
Previous Article Next Article

Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension

Author affiliations

Abstract

Diabetes and hypertension are important contributors to morbidity and mortality worldwide. Both of these conditions are caused by some combination of genetic and environmental factors which may include exposure to persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs). Studies have shown an association between elevated serum PCBs and the metabolic syndrome, insulin sensitivity and insulin secretion. Cross-sectional studies have shown associations between diabetes or hypertension and certain PCB congeners or classes, while those same studies show no association between diabetes or hypertension and several other PCB congeners. In animal and human cell studies, various PCBs and dioxins appear to alter glucose and insulin metabolism. These studies specifically show effects on the glucose transporter (GLUT-4) gene and protein; insulin-like growth factor binding protein-1 (IGFBP-1); nuclear transcription factor kappa B (NFκB); tumor necrosis factor alpha (TNF-α); and insulin production. There are a few longitudinal studies examining the association of diabetes or hypertension and PCBs with no consensus conclusion. Some longitudinal studies have found there to be an association, others have not and a gender difference has also been noted. Prospective studies are needed to determine if PCBs and other POPs contribute to development of diabetes and hypertension.

Graphical abstract: Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 04 Aug 2010, accepted on 04 Nov 2010 and first published on 02 Dec 2010


Article type: Critical Review
DOI: 10.1039/C0EM00400F
Citation: J. Environ. Monit., 2011,13, 241-251
  •   Request permissions

    Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension

    C. J. Everett, I. Frithsen and M. Player, J. Environ. Monit., 2011, 13, 241
    DOI: 10.1039/C0EM00400F

Search articles by author